An evidence-based checklist to assess neuropsychological outcomes of epilepsy surgery: How good is the evidence?

Improving the methodology for identifying mild cognitive impairment in older adults

This study by Dr. Grant Iverson, Dr. James Holdnack and Dr. Brian Brooks, published in 2012 in Alzheimer’s & Dementia, The Journal of the Alzheimer’s Association, set out to determine if changes in psychological measurements can improve the ability to diagnose mild cognitive impairment in older adults.


There are no accepted standard definitions or criteria for diagnosing mild cognitive impairment (MCI). Currently, a diagnosis is dependent on objective memory testing.


The purpose of this study is to examine and explore more effective ways MCI can be diagnosed.

Methods and Participants

A sample of 500 healthy older adults (65-90 years of age) participated as subject. They were given three learning and memory tests called the WMS-IV tests that look at logical memory, verbal paired associates and visual reproduction.

Results & Conclusions

The current guidelines and recommendations are not clear about the definition of memory impairment. With changes to the assessment the diagnosis of false positives and false negatives can be reduced. The criteria need to be refined in order to better diagnose patients.

Research by: Dr. Grant Iverson, Dr. James Holdnack and Dr. Brian Brooks

Published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association